Printed in the U.S.A. CAFFEINE STIMULATES B-ENDORPHIN RELEASE IN BLOOD BUT NOT IN CEREBROSPINAL FLUID
نویسندگان
چکیده
Plasma B-endorphin and prolactin profiles were obtained from groups of unstressed, adult male rats. The infusion of caffeine (20 mg/kg) via a chronic, indwelling intra-atrial cannula results in a prompt and sustained (2-2.5 h) rise in plasma B-endorphin levels. The infusion of the opiate antagonist naloxone causes a modest (40%) decrease in plasma 8-endorphin and blunts the elevation in plasma 8-endorphin following caffeine administration. In contrast, plasma prolactin levels were unchanged following caffeine administration and were decreased by treatment with naloxone. Caffeine treatment did not effect CSF 8-endorphin levels or the release of 8-endorphin from hemipituitaries incubated in vitro.
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